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VNN1 Protein (His tag)

VNN1 Origine: Humain Hôte: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
N° du produit ABIN7319167
  • Antigène Voir toutes VNN1 Protéines
    VNN1 (Vanin 1 (VNN1))
    Type de proteíne
    Recombinant
    Origine
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    Humain
    Source
    • 8
    • 3
    • 3
    • 2
    • 1
    Human Cells
    Purification/Conjugué
    Cette VNN1 protéine est marqué à la His tag.
    Fonction
    Recombinant Human VNN1/Vanin-1 Protein (His Tag)
    Séquence
    Gln22-Ser490
    Attributs du produit
    Recombinant Human Vascular Non-Inflammatory Molecule 1 is produced by our Mammalian expression system and the target gene encoding Gln22-Ser490 is expressed with a 6His tag at the C-terminus.
    Pureté
    > 95 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product VNN1 Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    VNN1 (Vanin 1 (VNN1))
    Autre désignation
    VNN1/Vanin-1 (VNN1 Produits)
    Synonymes
    HDLCQ8 Protein, Tiff66 Protein, V-1 Protein, hdlcq8 Protein, tiff66 Protein, vnn1.1 Protein, vanin-1 Protein, vanin 1 Protein, pantetheinase Protein, VNN1 Protein, Vnn1 Protein, vnn1 Protein, LOC100217969 Protein
    Sujet

    Background: Vanin-1 is a cell membrane protein which contains one CN hydrolase domain and belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 is also a member of the Vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. Vanin-1 is widely expressed with higher expression in spleen, kidney and blood and overexpressed in lesional psoriatic skin. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 Molecule was shown to be involved in the control of thymus reconstitution following sub-lethal irradiation.

    Synonym: Pantetheinase, Pantetheine Hydrolase, Tiff66, Vascular Non-Inflammatory Molecule 1, Vanin-1, VNN1

    Poids moléculaire
    53.3 kDa
    UniProt
    O95497
    Pathways
    Negative Regulation of intrinsic apoptotic Signaling
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