ZBP1 Protein (His tag)
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- Antigène Voir toutes ZBP1 Protéines
- ZBP1 (Z-DNA Binding Protein 1 (ZBP1))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette ZBP1 protéine est marqué à la His tag.
- Fonction
- Recombinant Human ZBP1 Protein (His Tag)
- Séquence
- Met 1-Ser149
- Attributs du produit
- Recombinant Human Z-DNA Binding Protein 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser149 is expressed with a 6His tag at the C-terminus.
- Pureté
- > 85 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product ZBP1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- ZBP1 (Z-DNA Binding Protein 1 (ZBP1))
- Autre désignation
- ZBP1 (ZBP1 Produits)
- Synonymes
- C20orf183 Protein, DAI Protein, DLM-1 Protein, DLM1 Protein, 2010010H03Rik Protein, Dai Protein, Dlm1 Protein, mZaDLM Protein, ZBP1 Protein, Z-DNA binding protein 1 Protein, ZBP1 Protein, Zbp1 Protein
- Sujet
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Background: Z-DNA Binding Protein 1 (ZBP1) is a protein with 2 DRADA repeats. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow, and spleen. ZBP1 participates in the detection of viral and bacterial DNA from by the host's innate immune system. It plays a role in host defense against tumors and pathogens. ZBP1 Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.
Synonym: Z-DNA-Binding Protein 1, Tumor Stroma and Activated Macrophage Protein DLM, ZBP1, C20orf183, DLM1
- Poids moléculaire
- 17.5 kDa
- UniProt
- Q9H171
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