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C5 Protéine

C5 Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
N° du produit ABIN7320495
  • Antigène Voir toutes C5 Protéines
    C5 (Complement Component 5 (C5))
    Type de proteíne
    Recombinant
    Origine
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Souris
    Source
    • 7
    • 4
    • 3
    • 1
    Escherichia coli (E. coli)
    Fonction
    Recombinant Mouse Complement Component C5/C5 Protein
    Séquence
    Asn679-Arg755
    Attributs du produit
    Recombinant Mouse Complement Component C5 is produced by our E.coli expression system and the target gene encoding Asn679-Arg755 is expressed.
    Pureté
    > 95 % as determined by SDS-PAGE
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product C5 Protéine
  • Commentaires

    12 kDa

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 350 mM NaCl, pH 7.5.
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    C5 (Complement Component 5 (C5))
    Autre désignation
    Complement Component C5 (C5 Produits)
    Synonymes
    C5 Protein, LOC565774 Protein, C5a Protein, C5b Protein, CPAMD4 Protein, Hc Protein, RGD1561905 Protein, He Protein, complement C5 Protein, complement component 5 Protein, hemolytic complement Protein, C5 Protein, c5 Protein, Hc Protein
    Sujet

    Background: Mouse Complement C5 (C5a) is a glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 77 amino acid peptide that is created by the C5a convertase proteolytic cleavage of C5 αchain in the classical and alternative complement pathway (C4b2a3b, C3bBb3b). Mouse C5a has fourαhelices, plus three intra-chain disulfide bonds that form a triple loop structure. C5a functions via G-protein coupled receptor (GPCR) (C5aR/CD88). C5a is a potent chemoattractant and anaphylatoxin that acts on all classes of leukocytes and on many other cell types including endothelial, smooth muscle, kidney, liver, and neural cells. It mediates IL-8 release from bronchial epithelial cells. It also triggers an oxidative burst in macrophages and neutrophils, causing release of histamine in basophils and mast cells. C5a anaphylatoxin activity on hepatocytes results indirectly from interaction with nonparenchymal cell via prostanoid secretion. Mouse C5a shares 60 % and 82 % sequence identity to human and rat C5a, respectively.

    Synonym: Complement C5, Hemolytic Complement, C5, Hc

    Poids moléculaire
    9.0 kDa
    UniProt
    P06684
    Pathways
    Système du Complément, Carbohydrate Homeostasis
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