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Sonic Hedgehog Protein (SHH)

SHH Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE. Active
N° du produit ABIN7319453
  • Antigène Voir toutes Sonic Hedgehog (SHH) Protéines
    Sonic Hedgehog (SHH)
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 11
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    Humain
    Source
    • 18
    • 14
    • 5
    • 1
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    • 1
    Escherichia coli (E. coli)
    Fonction
    Recombinant Human Sonic Hedgehog/SHH Protein (C24II)(Active)
    Séquence
    Cys24-Gly197(Cys24Ile-Ile)
    Attributs du produit
    Recombinant Human Sonic Hedgehog is produced by our E.coli expression system and the target gene encoding Cys24-Gly197(Cys24Ile-Ile) is expressed.
    Pureté
    > 95 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Immobilized Human SHH at 1μg/ml(100 μl/well) can bind Human BOC-His(Cat: PKSH032123).
    Top Product
    Discover our top product SHH Protéine
  • Commentaires

    20 kDa

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 100 mM NaCl, 1 mM DTT, pH 7.5.
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    Sonic Hedgehog (SHH)
    Autre désignation
    SHH (SHH Produits)
    Synonymes
    HHG1 Protein, HLP3 Protein, HPE3 Protein, MCOPCB5 Protein, SMMCI Protein, TPT Protein, TPTPS Protein, 9530036O11Rik Protein, Dsh Protein, Hhg1 Protein, Hx Protein, Hxl3 Protein, M100081 Protein, fc83d08 Protein, shh Protein, syu Protein, vhh-1 Protein, vhh1 Protein, wu:fc83d08 Protein, Xhh Protein, hedgehog Protein, xshh Protein, SHH Protein, twh Protein, twhh Protein, sonic hedgehog Protein, sonic hedgehog a Protein, sonic hedgehog L homeolog Protein, sonic hedgehog protein A Protein, sonic hedgehog b Protein, SHH Protein, Shh Protein, shha Protein, shh.L Protein, shh Protein, shhb Protein
    Sujet

    Background: Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called Hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles in regulating the patterning of many systems, such as limbs and brain. SHH also plays an important role in adult, including the division of adult stem cells and the development of certain cancers and other diseases. Human SHH is expressed as a 45 kDa precursor, and undergoes a series of processing during secretion. After the removal of the signal peptide, a protease within the C-terminal domain catalyzes the cleavage of SHH into a 20 kDa N-terminal signaling domain (SHH-N) and a 25 kDa C-terminal domain (SHH-C). SHH-N has the ""all signaling"" capability. SHH-N binds to the 12 pass transmembrane protein Patched (Ptc) on cell surface, which releases the repression of the activity of Smoothened (Smo), a G-protein coupled receptor, by Ptc.

    Synonym: Sonic Hedgehog Protein, SHH, HHG-1, SHH

    Poids moléculaire
    19.8 kDa
    UniProt
    Q15465
    Pathways
    Signalisation Hedgehog, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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