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CD24 Protein (Biotin)

CD24 Origine: Humain Hôte: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE. Active
N° du produit ABIN7319889
  • Antigène Voir toutes CD24 Protéines
    CD24 (CD24 Molecule (CD24))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Origine
    • 20
    • 5
    • 4
    • 1
    Humain
    Source
    • 22
    • 3
    • 2
    • 2
    • 1
    Human Cells
    Purification/Conjugué
    Cette CD24 protéine est marqué à la Biotin.
    Fonction
    Recombinant Human Signal Transducer CD24/CD24 (C-Fc-Avi) Biotinylated
    Séquence
    Ser27-Gly59
    Attributs du produit
    Biotinylated Recombinant Human Signal Transducer CD24 is produced by our Mammalian expression system and the target gene encoding Ser27-Gly59 is expressed with a Fc, Avi tag at the C-terminus.
    Pureté
    >95 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Immobilized Anti-Human CD24 mAb(Cat#NC050) at 2μg/ml (100 μl/well) can bind Biotinylated Human CD24-Fc-Avi(Cat#CY43). The ED50 of Biotinylated Human CD24-Fc-Avi(Cat#CY43) is 1.83 ng/ml.
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    Discover our top product CD24 Protéine
  • Commentaires

    40-55 kDa

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    CD24 (CD24 Molecule (CD24))
    Autre désignation
    CD24 (CD24 Produits)
    Synonymes
    CD24A Protein, Cd24a Protein, CD24 molecule Protein, CD24 Protein, Cd24 Protein
    Sujet

    Background: Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 Molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs.

    Synonym: Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen, CD24, CD24A

    Poids moléculaire
    31.6 kDa
    UniProt
    P25063
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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