Fc epsilon RI/FCER1A (FCER1A)
(Fc Fragment of IgE Receptor Ia (FCER1A))
Type de proteíne
Recombinant
Origine
Cynomolgus
Source
HEK-293 Cells
Purification/Conjugué
Cette Fc epsilon RI/FCER1A protéine est marqué à la His tag.
Fonction
Cynomolgus Fc epsilon RI alpha Protein, His Tag (SPR verified)
Séquence
Val 29 - Lys 204
Attributs du produit
Cynomolgus Fc epsilon RI alpha, His Tag (FCA-C52H9) is expressed from human 293 cells (HEK293). It contains AA Val 29 - Lys 204 (Accession # A0A7N9DA09-1).
BLI verified
FCER1A
Origine: Cynomolgus
Hôte: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
Indications d'application
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.3 kDa. The protein migrates as 35-55 kDa under reducing (R) condition due to glycosylation.
Restrictions
For Research Use only
Format
Lyophilized
Buffer
PBS, pH 7.4
Stock
-20 °C
Stockage commentaire
-20°C
Antigène
Fc epsilon RI/FCER1A (FCER1A)
(Fc Fragment of IgE Receptor Ia (FCER1A))
FCER1A Protein, FCE1A Protein, FcERI Protein, Iger01 Protein, RATIGER01 Protein, Fce1a Protein, Fcr-5 Protein, fcepsilonri Protein, Fc fragment of IgE receptor Ia Protein, Fc receptor, IgE, high affinity I, alpha polypeptide Protein, FCER1A Protein, Fcer1a Protein
Sujet
Synonyms:FCER1A,FCE1A,FcERI,Description:High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.