CD38 Protein (AA 43-300) (Fc Tag)

N° du produit ABIN7274151

Détail du produit

Antigène: CD38

Type de proteíne: Recombinant

Attributs du protein: AA 43-300

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CD38 protéine est marqué à la Fc Tag.

Fonction: Human CD38 Protein

Séquence: Val43-Ile300

Attributs du produit: Recombinant Human CD38 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Val43-Ile300.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human CD38, hFc Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Anti-CD38 Antibody, hFc Tag with the EC50 of 17.4ng/ml determined by ELISA. See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: CD38

Abstract: CD38 Produits

Synonymes: T10 Protein, Cd38-rs1 Protein, cd38 Protein, ADPRC 1 Protein, cADPr hydrolase 1 Protein, CD38 molecule Protein, CD38 antigen Protein, CD38 molecule L homeolog Protein, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Protein, CD38 Protein, Cd38 Protein, cd38.L Protein

Sujet: CD38 is highly and uniformly expressed on multiple myeloma (MM) cells, and at relatively low levels on normal lymphoid and myeloid cells, and in some tissues of nonhematopoietic origin. CD38 is a transmembrane glycoprotein with ectoenzymatic activity, and also functions as a receptor and adhesion molecule. Altogether, this has triggered the development of several CD38 antibodies including daratumumab (fully human), isatuximab (chimeric), and MOR202 (fully human).

Poids moléculaire: 56.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.