CD96 Protein (CD96) (Cys110Ser-Mutant) (His tag)

N° du produit ABIN7274267

Détail du produit

Antigène: CD96

Type de proteíne: Recombinant

Attributs du protein: Cys110Ser-Mutant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CD96 protéine est marqué à la His tag.

Fonction: Human CD96/TACTILE (C110S) Protein

Séquence: Val22-Met503 (C110S)

Attributs du produit: Recombinant Human CD96/TACTILE (C110S) Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val22-Met503(C110S).

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human CD96 (C110S) , His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-CD96 Antibody, hFc Tag with the EC50 of 0.17ug/ml determined by ELISA. See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: CD96

Autre désignation: CD96 (CD96 Produits)

Sujet: The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development.

Poids moléculaire: 54.63 kDa. Due to glycosylation, the protein migrates to 100-130 kDa based on Tris-Bis PAGE result.