NOTCH3 Protein (AA 40-467) (Fc Tag)
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- Antigène Voir toutes NOTCH3 Protéines
- NOTCH3 (Notch 3 (NOTCH3))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 40-467
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette NOTCH3 protéine est marqué à la Fc Tag.
- Fonction
- Human Notch 3 Protein
- Séquence
- Ala40-Glu467
- Attributs du produit
- Recombinant Human Notch 3 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ala40-Glu467.
- Pureté
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
- Top Product
- Discover our top product NOTCH3 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- NOTCH3 (Notch 3 (NOTCH3))
- Autre désignation
- Notch 3 (NOTCH3 Produits)
- Synonymes
- CADASIL Protein, CASIL Protein, IMF2 Protein, AW229011 Protein, N3 Protein, hpbk Protein, fa14b08 Protein, notch5 Protein, wu:fa14b08 Protein, notch 3 Protein, NOTCH3 Protein, Notch3 Protein, notch3 Protein
- Sujet
- Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs
- Poids moléculaire
- 71.53 kDa. Due to glycosylation, the protein migrates to 75-83 kDa based on Tris-Bis PAGE result.
- UniProt
- Q9UM47
- Pathways
- Signalisation Notch
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