C5 Protein (Biotin,His-Avi Tag)

N° du produit ABIN7316821

Détail du produit

Antigène: C5 (Complement Component 5 (C5))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette C5 protéine est marqué à la Biotin,His-Avi Tag.

Fonction: Biotinylated Human Complement C5 Protein, His,Avitag™

Séquence: Gln 19 - Cys 1676

Attributs du produit: Biotinylated Human Complement C5, His,Avitag is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Cys 1676 (Accession # P01031-1).

Pureté: 95,00 %

niveau d'endotoxine: 1.0 EU per μg

Information d'application

Commentaires:

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 189.9 kDa. As a result of glycosylation, the protein migrates as 75 kDa, 120 kDa and 200 kDa under reducing (R) condition, and 200 kDa under non-reducing (NR) condition (SDS-PAGE).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: C5 (Complement Component 5 (C5))

Autre désignation: Complement C5 (C5 Produits)

Synonymes: C5 Protein, LOC565774 Protein, C5a Protein, C5b Protein, CPAMD4 Protein, Hc Protein, RGD1561905 Protein, He Protein, complement C5 Protein, complement component 5 Protein, hemolytic complement Protein, C5 Protein, c5 Protein, Hc Protein

Sujet: Synonyms:Complement C5,C5,CPAMD4,Description:Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Poids moléculaire: 189.9 kDa

NCBI Accession: NP_001726

Pathways: Système du Complément, Carbohydrate Homeostasis