BTLA Protein (AA 30-176) (mFc Tag)

N° du produit ABIN7490631

Détail du produit

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Type de proteíne: Recombinant

Attributs du protein: AA 30-176

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette BTLA protéine est marqué à la mFc Tag.

Fonction: Recombinant mouse BTLA protein with C-terminal mFc tag

Specificité: Mouse BTLA (Glu30-Pro176) mFc (Pro99-Lys330)

Attributs du produit: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Autre désignation: BTLA (BTLA Produits)

Synonymes: BTLA Protein, BTLA1 Protein, CD272 Protein, A630002H24 Protein, B and T lymphocyte associated Protein, BTLA Protein, Btla Protein

Sujet: Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).

Poids moléculaire: predicted molecular mass of 42.7 kDa after removal of the signal peptide.The apparent molecular mass of Mouse-BTLA-mFc is 55-70 kDa due to glycosylation.

UniProt: Q7TSA3

Pathways: Cancer Immune Checkpoints