IL18BP Protein (AA 31-192) (Fc Tag)

N° du produit ABIN7490683

Détail du produit

Antigène: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Type de proteíne: Recombinant

Attributs du protein: AA 31-192

Origine: Chien

Source: HEK-293 Cells

Purification/Conjugué: Cette IL18BP protéine est marqué à la Fc Tag.

Fonction: Recombinant Canis IL18BP protein with C-terminal human Fc tag

Specificité: IL18BP (Thr31-Phe192) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Autre désignation: IL18BP (IL18BP Produits)

Synonymes: IL18BP Protein, IL-18BP Protein, Igifbp Protein, MC54L Protein, IL18BPa Protein, interleukin 18 binding protein Protein, IL18BP Protein, Il18bp Protein

Sujet: Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

Poids moléculaire: predicted molecular mass of 43.7 kDa after removal of the signal peptide.The apparent molecular mass of dIL18BP-hFc is 55-70 kDa due to glycosylation.

UniProt: F1PLB5