NPR1 Protein (AA 33-473) (Fc Tag)

N° du produit ABIN7491179

Détail du produit

Antigène: NPR1 (Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))

Type de proteíne: Recombinant

Attributs du protein: AA 33-473

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette NPR1 protéine est marqué à la Fc Tag.

Fonction: Recombinant human NPR1 protein with C-terminal human Fc tag

Specificité: NPR1 (Gly33-Glu473) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: NPR1 (Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1))

Autre désignation: NPR1 (NPR1 Produits)

Synonymes: ANPRA Protein, ANPa Protein, GUC2A Protein, GUCY2A Protein, NPRA Protein, Anpra Protein, Gca Protein, NPR-A Protein, Npra Protein, sGC Protein, si:dkey-27c15.1 Protein, AI893888 Protein, GC-A Protein, Pndr Protein, ARABIDOPSIS NONEXPRESSER OF PR GENES 1 Protein, ATNPR1 Protein, F15H21.6 Protein, F15H21_6 Protein, NIM1 Protein, NON-INDUCIBLE IMMUNITY 1 Protein, NONEXPRESSER OF PR GENES 1 Protein, REGULATORY PROTEIN NPR1 Protein, SAI1 Protein, SALICYLIC ACID INSENSITIVE 1 Protein, natriuretic peptide receptor 1 Protein, natriuretic peptide receptor 1a Protein, regulatory protein (NPR1) Protein, NPR1 Protein, Npr1 Protein, npr1a Protein

Sujet: Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides, they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2, MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

Poids moléculaire: predicted molecular mass of 75.0 kDa after removal of the signal peptide. The apparent molecular mass of NPR1-hFc is 95-130 kDa due to glycosylation.

UniProt: P16066