MYDGF (D17Wsu104e)
(DNA segment, Chr 17, Wayne State University 104, expressed (D17Wsu104e))
Type de proteíne
Recombinant
Origine
Humain
Source
Escherichia coli (E. coli)
Purification/Conjugué
Cette MYDGF protéine est marqué à la His tag.
Fonction
Recombinant Human Myeloid-derived Growth Factor is produced by our E.coli expression system and the target gene encoding Ser33-Leu173 is expressed with a 6His tag at the N-terminus.
Attributs du produit
Extracellular Domain Protein
Purification
Affinity purification
Pureté
Greater than 95 % as determined by reducing SDS-PAGE.
D17Wsu104e
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
> 95 % by SDS - PAGE
SDS
Restrictions
For Research Use only
Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution of 4 mM HCl.
Stock
-20 °C,-80 °C
Stockage commentaire
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Date de péremption
12 months
Antigène
MYDGF (D17Wsu104e)
(DNA segment, Chr 17, Wayne State University 104, expressed (D17Wsu104e))
Myeloid-derived growth factor (MYDGF) is a secreted protein which belongs to the UPF0556 family. MYDGF was strongly expressed in spleen, prostate and lung, and weakly expressed in the left ventricle and liver. Bone marrow-derived monocyte and paracrine-acting protein promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). MYDGF stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. It inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway. MYDGF is involved in endothelial cell proliferation and angiogenesis. It may serve as a prototypical example for the development of protein-based therapies for ischemic tissue repair.