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Sonic Hedgehog Protein (SHH) (His tag)

SHH Origine: Humain Hôte: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
N° du produit ABIN7455651
  • Antigène Voir toutes Sonic Hedgehog (SHH) Protéines
    Sonic Hedgehog (SHH)
    Type de proteíne
    Recombinant
    Origine
    • 11
    • 9
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
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    • 1
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    Humain
    Source
    • 18
    • 15
    • 4
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification/Conjugué
    Cette Sonic Hedgehog protéine est marqué à la His tag.
    Fonction
    Recombinant Human Sonic Hedgehog is produced by our Mammalian expression system and the target gene encoding Cys24-Gly197 is expressed with a 6His tag at the C-terminus.
    Attributs du produit
    Extracellular Domain Protein
    Purification
    Purified from cell culture supernatant by affinity chromatography
    Pureté
    Greater than 95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product SHH Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Date de péremption
    12 months
  • Antigène
    Sonic Hedgehog (SHH)
    Autre désignation
    SHH (SHH Produits)
    Synonymes
    HHG1 Protein, HLP3 Protein, HPE3 Protein, MCOPCB5 Protein, SMMCI Protein, TPT Protein, TPTPS Protein, 9530036O11Rik Protein, Dsh Protein, Hhg1 Protein, Hx Protein, Hxl3 Protein, M100081 Protein, fc83d08 Protein, shh Protein, syu Protein, vhh-1 Protein, vhh1 Protein, wu:fc83d08 Protein, Xhh Protein, hedgehog Protein, xshh Protein, SHH Protein, twh Protein, twhh Protein, sonic hedgehog Protein, sonic hedgehog a Protein, sonic hedgehog L homeolog Protein, sonic hedgehog protein A Protein, sonic hedgehog b Protein, SHH Protein, Shh Protein, shha Protein, shh.L Protein, shh Protein, shhb Protein
    Sujet
    Sonic Hedgehog Homolog (SHH) belongs to a three-protein family called hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles in regulating the patterning of many systems, such as limbs and brain. SHH also plays an important role in adult, including the division of adult stem cells and the development of certain cancers and other diseases. Human SHH is expressed as a 45 kDa precursor, and undergoes a series of processing during secretion. After the removal of the signal peptide, a protease within the C-terminal domain catalyzes the cleavage of SHH into a 20 kDa N-terminal signaling domain (SHH-N) and a 25 kDa C-terminal domain (SHH-C). SHH-N has the ""all signaling"" capability. SHH-N binds to the 12 pass transmembrane protein Patched (Ptc) on cell surface, which releases the repression of the activity of Smoothened (Smo), a G-protein coupled receptor, by Ptc.
    Poids moléculaire
    20.4 KDa
    UniProt
    Q15465
    Pathways
    Signalisation Hedgehog, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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