CCR4 Protéine

N° du produit ABIN7491562

Détail du produit

Antigène: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Type de proteíne: Synthetic Nanodisc

Origine: Humain

Source: HEK-293 Cells

Fonction: Human CCR4 full length protein-synthetic nanodisc

Attributs du produit: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Information d'application

Commentaires:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Autre désignation: CCR4 (CCR4 Produits)

Synonymes: CC-CKR-4 Protein, CD194 Protein, CKR4 Protein, CMKBR4 Protein, ChemR13 Protein, HGCN:14099 Protein, K5-5 Protein, Ccr4 Protein, C-C CKR-4 Protein, CHEMR1 Protein, Cmkbr4 Protein, LESTR Protein, Sdf1r Protein, C-C motif chemokine receptor 4 Protein, chemokine (C-C motif) receptor 4 Protein, CCR4 Protein, Ccr4 Protein

Sujet: The protein belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Poids moléculaire: The human full length CCR4 Protein has a MW of 41.4 kDa

UniProt: P51679