TSH receptor Protéine

N° du produit ABIN7491755

Détail du produit

Antigène: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Type de proteíne: Synthetic Nanodisc

Origine: Humain

Source: HEK-293 Cells

Fonction: Human TSHR full length protein-synthetic nanodisc

Attributs du produit: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Information d'application

Commentaires:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Autre désignation: TSHR (TSHR Produits)

Synonymes: CHNG1 Protein, LGR3 Protein, hTSHR-I Protein, AI481368 Protein, hypothroid Protein, hyt Protein, pet Protein, TSHRA Protein, TSH-R Protein, thyroid stimulating hormone receptor Protein, tshr Protein, TSHR Protein, Tshr Protein

Sujet: The protein is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism.

Poids moléculaire: The human full length TSHR protein has a MW of 86.8 kDa

UniProt: P16473

Pathways: Thyroid Hormone Synthesis