CCR1 Protéine
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- Antigène Voir toutes CCR1 Protéines
- CCR1 (Chemokine (C-C Motif) Receptor 1 (CCR1))
- Type de proteíne
- Synthetic Nanodisc
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Origine
- Humain
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Source
- HEK-293 Cells
- Fonction
- Human CCR1 full length protein-synthetic nanodisc
- Attributs du produit
- Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
- Top Product
- Discover our top product CCR1 Protéine
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- Commentaires
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Advantages of Synthetic Nanodiscs:
- Highly purified membrane proteins
- High solubility in aqueous solutions
- High stability
- Proteins are in a native membrane environment and remain biologically active
- No detergent and can be used for cell-based assays
- No MSP backbone proteins
- Intolerant to acids and high concentrations of divalent metal ions
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Date de péremption
- 12 months
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- Antigène
- CCR1 (Chemokine (C-C Motif) Receptor 1 (CCR1))
- Autre désignation
- CCR1 (CCR1 Produits)
- Synonymes
- CD191 Protein, CKR-1 Protein, CKR1 Protein, CMKBR1 Protein, HM145 Protein, MIP1aR Protein, SCYAR1 Protein, Cmkbr1 Protein, Mip-1a-R Protein, C-C motif chemokine receptor 1 Protein, chemokine (C-C motif) receptor 1 Protein, CCR1 Protein, Ccr1 Protein
- Sujet
- A member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.
- Poids moléculaire
- The human full length CCR1 protein has a MW of 41.2 kDa
- UniProt
- P32246
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