CXCR3 Protein-VLP

N° du produit ABIN7488804

Détail du produit

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Type de proteíne: VLP

Origine: Humain

Source: HEK-293 Cells

Fonction: Human CXCR3 Full Length Protein (VLP)

Séquence: Val 2 - Leu 368

Attributs du produit: Human CXCR3 Full Length Protein-VLP is expressed from human 293 cells (HEK293). It contains AA Val 2 - Leu 368 (Accession # P49682-1).

niveau d'endotoxine: 1.0 EU per μg

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, Arginine, pH 7.4

Stock: -80 °C

Stockage commentaire: -70°C

Détail du antigène

Antigène: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Autre désignation: CXCR3 (CXCR3 Produits)

Synonymes: CD182 Protein, CD183 Protein, CKR-L2 Protein, CMKAR3 Protein, GPR9 Protein, IP10-R Protein, Mig-R Protein, MigR Protein, Cd183 Protein, Cmkar3 Protein, CXCR3 Protein, cxcr3 Protein, Gpr9 Protein, CXC-R3 Protein, CXCR-3 Protein, zgc:92301 Protein, sb:eu378 Protein, C-X-C motif chemokine receptor 3 Protein, chemokine (C-X-C motif) receptor 3 Protein, chemokine (C-X-C motif) receptor 3, tandem duplicate 2 Protein, chemokine (C-X-C motif) receptor 3, tandem duplicate 1 Protein, CXCR3 Protein, Cxcr3 Protein, cxcr3 Protein, cxcr3.2 Protein, cxcr3.1 Protein

Sujet: Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells, and cause tissue extravasation. Given these properties, their role in anti-tumor immune response in the cancer environment is of great interest. Although immunotherapy has shown clinical benefit for some cancer patients, other patients do not respond. One of the mechanisms of resistance to checkpoint inhibitors may be chemokine signaling. The CXCL9, -10, -11/CXCR3 axis regulates immune cell migration, differentiation, and activation, leading to tumor suppression (paracrine axis). However, there are some reports that show involvements of this axis in tumor growth and metastasis (autocrine axis). Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control.