Tspan-8 Protein (His tag)

N° du produit ABIN7488814

Détail du produit

Antigène: Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette Tspan-8 protéine est marqué à la His tag.

Fonction: Mouse TSPAN8 Protein, His Tag (MALS verified)

Séquence: Gly 106 - Asn 203

Attributs du produit: Mouse TSPAN8 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Gly 106 - Asn 203 (Accession # Q8R3G9-1).

Pureté: 90 %

niveau d'endotoxine: 1.0 EU per μg

Classe de qualité: MALS verified

Information d'application

Commentaires:

This protein carries a polyhistidine tag at the N-terminus. (10xHis) The protein has a calculated MW of 12.8 kDa. The protein migrates as 15-19 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))

Autre désignation: TSPAN8 (TSPAN8 Produits)

Synonymes: tm4sf3 Protein, MGC64550 Protein, GB13255 Protein, TM4SF3 Protein, tetraspanin-8 Protein, tspan8 Protein, TSPAN8 Protein, CO-029 Protein, C76990 Protein, E330007O21Rik Protein, Tm4sf3 Protein, CO-29 Protein, TSPAN-8 Protein, tetraspanin 8 L homeolog Protein, tetraspanin-1 Protein, tetraspanin 8 Protein, tspan8.L Protein, LOC409511 Protein, TSPAN8 Protein, tspan8 Protein, Tspan8 Protein

Sujet: Tspan8 is 1 of the 33 mammalian members of the tetraspanin family, composed of transmembrane proteins that organize laterally, together or with other membrane partners such as integrins, to form 'tetraspanin webs'. These platforms signal within cells to regulate many cellular processes: adhesion, migration, invasion or survival Tspan8 has been implicated in many types of cancer.Overexpression was reported in glioma and colorectal, esophageal, hepatic, gastric and pancreatic carcinoma. Tspan8 exerts a pro-invasive function by controlling cell-cell and cell-matrix interactions through its association with membrane partners such as α6β4 integrin-protein kinase C (PKC)-activated, E-cadherin, EpCAM, claudin-7 and CD44. Moreover, Tspan8 may be a promising new therapeutic target, as Tspan8-specific antibodies were shown to reduce cell motility, block tumor angiogenesis in vivo.

Poids moléculaire: 12.8 kDa