Src Protein (AA 2-287) (His tag)

N° du produit ABIN7504942

Détail du produit

Antigène: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Type de proteíne: Recombinant

Attributs du protein: AA 2-287

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Src protéine est marqué à la His tag.

Séquence: Gly2-Gly287

Attributs du produit: A DNA sequence encoding the Human SRC (P12931-1) (Gly2-Gly287) was expressed with a polyhistidine tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Autre désignation: SRC (Src Produits)

Synonymes: AW259666 Protein, pp60c-src Protein, C-src1 Protein, CG7524 Protein, D-Src64B Protein, D-src Protein, DSRC64 Protein, DSrc Protein, DSrc64 Protein, DSrc64B Protein, Dm SRC1 Protein, DmHD-358 Protein, Dmel\CG7524 Protein, Dsrc Protein, Dsrc64 Protein, Dsrc64B Protein, HD-358 Protein, MRE5 Protein, SRC 64B Protein, Src Protein, Src1 Protein, Src64 Protein, c-src Protein, dSrc Protein, dsrc Protein, src Protein, src1 Protein, src64 Protein, src64B Protein, src64b Protein, ASV Protein, SRC1 Protein, c-SRC Protein, p60-Src Protein, c-Src Protein, PP60C-SCR Protein, SDR Protein, SRC proto-oncogene, non-receptor tyrosine kinase Protein, uncharacterized LOC5574802 Protein, proto-oncogene tyrosine-protein kinase src Protein, Rous sarcoma oncogene Protein, Src oncogene at 64B Protein, SRC Protein, LOC5574802 Protein, CpipJ_CPIJ010659 Protein, Src Protein, Src64B Protein

Classe de substances: Viral Protein

Sujet:

Abbreviation: SRC,Proto-oncogene c-Src

Target Synonym: Proto-oncogene tyrosine-protein kinase Src,Proto-oncogene c-Src,pp60c-src,p60-Src,SRC1

Background: Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.

Poids moléculaire:

Calculated MW: 31.19 kDa

Observed MW: 33.39 kDa

UniProt: P12931-1

Pathways: Signalistation JAK/STAT, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling