RAGE Protein (AA 23-342) (His tag)
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- Antigène Voir toutes RAGE (AGER) Protéines
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 23-342
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette RAGE protéine est marqué à la His tag.
- Séquence
- Ala23-Ala342
- Attributs du produit
- A DNA sequence encoding theHuman AGER protein (Q15109) (Ala23-Ala342 ) was expressed with a N-His.
- Pureté
- > 85 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product AGER Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- Autre désignation
- AGER (AGER Produits)
- Synonymes
- RAGE Protein, AGER Protein, advanced glycosylation end-product specific receptor Protein, advanced glycosylation end product-specific receptor Protein, MAPK/MAK/MRK overlapping kinase Protein, AGER Protein, Ager Protein, LOC719012 Protein
- Sujet
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Abbreviation: AGER
Target Synonym: Receptor for advanced glycosylation end products
Background: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
- Poids moléculaire
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Calculated MW: 34 kDa
Observed MW: 38 kDa
- UniProt
- Q15109
- Pathways
- Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
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