PIBF1 Protein (AA 13-203) (His tag)
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- Antigène Voir toutes PIBF1 Protéines
- PIBF1 (Progesterone Immunomodulatory Binding Factor 1 (PIBF1))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 13-203
- Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette PIBF1 protéine est marqué à la His tag.
- Séquence
- Asn 13-Val 203
- Attributs du produit
- A DNA sequence encoding the Human PIBF protein (Q8WXW3) (Asn 13-Val 203) was expressed with a N-His tag.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product PIBF1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- PIBF1 (Progesterone Immunomodulatory Binding Factor 1 (PIBF1))
- Autre désignation
- PIBF (PIBF1 Produits)
- Synonymes
- D14Ertd581e Protein, 1700017E21Rik Protein, 4930513H15Rik Protein, 4933438D16Rik Protein, 4933439E17Rik Protein, RGD1305077 Protein, PIBF Protein, C13orf24 Protein, zgc:101063 Protein, MGC80410 Protein, CEP90 Protein, RP11-505F3.1 Protein, progesterone immunomodulatory binding factor 1 Protein, progesterone immunomodulatory binding factor 1 S homeolog Protein, Pibf1 Protein, PIBF1 Protein, pibf1 Protein, pibf1.S Protein
- Sujet
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Abbreviation: PIBF
Target Synonym: C13orf24,KIAA1008,PIBF 1,PIBF,PIBF1,PIBF1,Progesterone immunomodulatory binding factor 1,Progesterone induced blocking factor 1
Background: PIBF-1 (Progesterone induced blocking factor 1) is a 90-92 kDa progesterone-inducible molecule initially isolated from the lymphocytes of pregnant women. It is produced by lymphocytes plus villous trophoblast cells, and modulates the activity of cytotoxic NK cells. Human PIBF-1 is 757 amino acids (aa) in length. It contains a possible signal sequence (aa 1-26), two Leu-zippers (aa 311-323 and 643-664), two NLSs (aa 282-285 and 567-573), a bZIP sequence (aa 574-614), and an ER retention motif (aa 752-757). PIBF-1 is found in the nucleus, cytoplasm, and circulation, the result of multiple splice variants. SDS-page shows 90 kDa, 80-83 kDa, 48-52 kDa, 34-35 kDa, and 10-12 kDa isoforms. The 90 kDa form is nuclear and full-length, while the 34-35 kDa form is secreted and likely represents aa 1-223 spliced to aa 683-757. There is a 50-55 kDa form that is apparently intracellular, possibly bioactive and likely represents the N-terminus of the molecule. Over aa 19?419, human PIBF-1 shares 88 % aa identity with mouse PIBF-1.
- Poids moléculaire
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Calculated MW: 20.9 kDa
Observed MW: 28 kDa
- UniProt
- Q8WXW3
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