C1QTNF9 Protein (AA 20-333) (His tag)

N° du produit ABIN7505063

Détail du produit

Antigène: C1QTNF9 (C1q and Tumor Necrosis Factor Related Protein 9 (C1QTNF9))

Type de proteíne: Recombinant

Attributs du protein: AA 20-333

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette C1QTNF9 protéine est marqué à la His tag.

Séquence: Gln 0-Pro 333

Attributs du produit: A DNA sequence encoding the Human C1QTNF9 protein (P0C862) (Gln 20-Pro 333) was expressed with a N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: C1QTNF9 (C1q and Tumor Necrosis Factor Related Protein 9 (C1QTNF9))

Autre désignation: C1QTNF9 (C1QTNF9 Produits)

Synonymes: AQL1 Protein, C1QTNF9A Protein, CTRP9 Protein, 9130217G22Rik Protein, Ciqtnf9 Protein, C1q and TNF related 9 Protein, C1q and tumor necrosis factor related protein 9 Protein, C1QTNF9 Protein, C1qtnf9 Protein

Sujet:

Abbreviation: C1QTNF9

Target Synonym: AQL1,C1q and tumor necrosis factor related protein 9,C1qTNF9,CTRP9,MGC48915,C1QTNF9A

Background: C1qTNF9, also known as CTRP9, is an approximately 40 kDa member of the C1q and TNF-related protein family. Like all members of this protein family, C1qTNF9 consists of a short variable region, a collagenous domain that can be hydroxylated, and a C1q-like globular domain. Human C1qTNF9 shares 85 % amino acid sequence identity with the mouse and rat orthologs. Both the mouse and human C1qTNF9 proteins are expressed in adipose tissue, but the mouse protein has also been detected in the heart, lung, muscle, kidney, testis, lymph node, smooth muscle, prostate, thymus, and uterus. They have both also been shown to be secreted as trimers and higher order multimers and also to form hetero-oligomers with Adiponectin. Mouse C1qTNF9 can stimulate the phosphorylation of AMPK, Akt, and eNOS. Also in mice, C1qTNF9 may have an important role in cardiac and metabolic health. Its expression has a cardioprotective effect following acute myocardial infarction that may be dependent on AMPK activation. Additionally, transgenic mice overexpressing C1qTNF9 are resistant to high fat diet?induced obesity. This metabolic role may be conserved, since C1qTNF9 serum levels have been shown to inversely correlate with metabolic syndrome in humans.

Poids moléculaire:

Calculated MW: 34.43 kDa

Observed MW: 35 kDa

UniProt: P0C862