Kallikrein 7 Protein (KLK7) (AA 23-253) (His tag)

N° du produit ABIN7505077

Détail du produit

Antigène: Kallikrein 7 (KLK7)

Type de proteíne: Recombinant

Attributs du protein: AA 23-253

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Kallikrein 7 protéine est marqué à la His tag.

Séquence: Glu 23-Arg 253

Attributs du produit: A DNA sequence encoding the Human KLK7 protein (P49862) (Glu23-Arg253) was expressed with a N-His .

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Kallikrein 7 (KLK7)

Autre désignation: KLK7 (KLK7 Produits)

Synonymes: Prss6 Protein, SCCE Protein, PRSS6 Protein, hK7 Protein, kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Protein, kallikrein-related peptidase 7 Protein, kallikrein related peptidase 7 Protein, Klk7 Protein, KLK7 Protein

Sujet:

Abbreviation: KLK7

Target Synonym: Kallikrein-7,hK7,Serine Protease 6,Stratum Corneum Chymotryptic Enzyme,hSCCE,KLK7,PRSS6,SCCE

Background: Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.

Poids moléculaire:

Calculated MW: 25.3 kDa

Observed MW: 31 kDa

UniProt: P49862

Pathways: Système du Complément