MASP1 Protein (AA 20-447) (His tag)

N° du produit ABIN7505079

Détail du produit

Antigène: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Type de proteíne: Recombinant

Attributs du protein: AA 20-447

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette MASP1 protéine est marqué à la His tag.

Séquence: His 20-Ala 447

Attributs du produit: A DNA sequence encoding the Human MASP1 protein (P48740) (His20-Ala447) was expressed with a N-His .

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: MASP1 (Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Autre désignation: MASP1 (MASP1 Produits)

Synonymes: AW048060 Protein, CCPII Protein, Crarf Protein, Masp1/3 Protein, 3MC1 Protein, CRARF Protein, CRARF1 Protein, MAP1 Protein, MASP Protein, MASP3 Protein, MAp44 Protein, PRSS5 Protein, RaRF Protein, mannan-binding lectin serine peptidase 1 Protein, mannan binding lectin serine peptidase 1 Protein, Masp1 Protein, MASP1 Protein

Sujet:

Abbreviation: MASP1

Target Synonym: Mannan-Binding Lectin Serine Protease 1,Complement Factor MASP-3,Mannose-Binding Lectin-Associated Serine Protease 1,MASP-1,RaRF,Serine Protease 5,MASP1,CRARF,CRARF1,PRSS5

Background: Mannan-Binding Lectin Serine Protease 1 (MASP-1) belongs to the peptidase S1 family. MASP1 contains two CUB domains, one EGF-like domain, one peptidase S1 domain and two Sushi (CCP/SCR) domains. MASP1 is primarily expressed in liver. MASP1 involved in the lectin pathway of the complement, performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. MASP1 is synthesized as a zymogen and activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. MASP1 is not directly involved in complement activation but may act as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP2. MASP1 is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. MASP1 is inhibited by SERPING1 and A2M.

Poids moléculaire:

Calculated MW: 46.97 kDa

Observed MW: 48 kDa

UniProt: P48740

Pathways: Système du Complément