FLNC Protein (AA 2519-2725) (His tag)

N° du produit ABIN7505105

Détail du produit

Antigène: FLNC (Filamin C, gamma (FLNC))

Type de proteíne: Recombinant

Attributs du protein: AA 2519-2725

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette FLNC protéine est marqué à la His tag.

Séquence: Thr 2519-Pro 2725

Attributs du produit: A DNA sequence encoding the Human FLNC protein (Q14315) (Thr 2519-Pro 2725) was expressed with a N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: FLNC (Filamin C, gamma (FLNC))

Autre désignation: FLNC (FLNC Produits)

Synonymes: 1110055E19Rik Protein, ABP-280 Protein, ABPL Protein, Fln2 Protein, ABP280A Protein, ABPA Protein, FLN2 Protein, MFM5 Protein, MPD4 Protein, filamin C Protein, filamin C L homeolog Protein, filamin C, gamma Protein, FLNC Protein, flnc.L Protein, flnc Protein, Flnc Protein

Sujet:

Abbreviation: FLNC

Target Synonym: Filamin C ,FIlamin 2,Filamin C,FLN2,FLNC,ABPL,FLN2

Background: FLNC is a muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z-disks in muscle cells. Defects in FLNC are the cause of autosomal dominant filaminopathy. Myofibrillar myopathy (MFM) is a neuromuscular disorder, usually with an adult onset, characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations. Autosomal dominant filaminopathy is a form of MFM characterized by morphological features of MFM and clinical features of a limb-girdle myopathy. A heterozygous nonsense mutation which segregates with the disease, has been identified in the FLNC gene.

Poids moléculaire:

Calculated MW: 22.66 kDa

Observed MW: 28 kDa

UniProt: Q14315