BDNF Protein (AA 129-247) (His tag)

N° du produit ABIN7505123

Détail du produit

Antigène: BDNF (Brain-Derived Neurotrophic Factor (BDNF))

Type de proteíne: Recombinant

Attributs du protein: AA 129-247

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette BDNF protéine est marqué à la His tag.

Séquence: His 129-Arg 247

Attributs du produit: A DNA sequence encoding the Human BDNF protein (P23560) (His 129-Arg 247) was expressed with a N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: BDNF (Brain-Derived Neurotrophic Factor (BDNF))

Autre désignation: BDNF (BDNF Produits)

Synonymes: ANON2 Protein, BULN2 Protein, bdnf-A Protein, BDNF Protein, bdnf Protein, brain derived neurotrophic factor Protein, brain-derived neurotrophic factor Protein, brain-derived neurotrophic factor L homeolog Protein, brain-derived neurotrophic factor S homeolog Protein, BDNF Protein, Bdnf Protein, bdnf Protein, bdnf.L Protein, bdnf.S Protein

Sujet:

Abbreviation: BDNF

Target Synonym: Brain-Derived Neurotrophic Factor,BDNF,Abrineurin

Background: The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.

Poids moléculaire:

Calculated MW: 12.98 kDa

Observed MW: 15 kDa

UniProt: P23560

Pathways: Signalisation RTK, Synaptic Membrane, Feeding Behaviour, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity