Calnexin Protein (CANX) (AA 21-251) (His tag)

N° du produit ABIN7505154

Détail du produit

Antigène: Calnexin (CANX)

Type de proteíne: Recombinant

Attributs du protein: AA 21-251

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Calnexin protéine est marqué à la His tag.

Séquence: His 21-Leu 251

Attributs du produit: A DNA sequence encoding the Human CANX protein (P27824) (His 21-Leu 251) was expressed with a N-10His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Calnexin (CANX)

Autre désignation: Calnexin (CANX Produits)

Synonymes: CNX Protein, IP90 Protein, P90 Protein, 1110069N15Rik Protein, AI988026 Protein, Cnx Protein, D11Ertd153e Protein, canx Protein, clgn Protein, clnx Protein, cnx Protein, PP90 Protein, zgc:63524 Protein, wu:fe06b12 Protein, CANX Protein, calnexin Protein, CalNeXin Protein, calnexin L homeolog Protein, CANX Protein, Canx Protein, cnx-1 Protein, canx.L Protein, canx Protein, LOC100283947 Protein

Sujet:

Abbreviation: Calnexin,CANX

Target Synonym: Calnexin,IP90,Major Histocompatibility Complex Class I Antigen-Binding Protein p88,p90,CANX

Background: Calnexin/CANX is a single-pass type I membrane protein which belongs to the calreticulin family. It consists of a large N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. The function of calnexin is to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum. Calnexin is a calcium-binding protein that interacts briefly with newly synthesized glycoproteins in the endoplasmic reticulum. Calnexin may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. Calnexin seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Calnexin dwindles with aging and might contribute to a cytoprotection in an array of human age-related diseases.

Poids moléculaire:

Calculated MW: 25.3 kDa

Observed MW: 42 kDa

UniProt: P27824

Pathways: Signalisation MAPK, Thyroid Hormone Synthesis