Nanog Protein (AA 94-162) (His tag)

N° du produit ABIN7505155

Détail du produit

Antigène: Nanog (NANOG) (Nanog Homeobox (NANOG))

Type de proteíne: Recombinant

Attributs du protein: AA 94-162

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Nanog protéine est marqué à la His tag.

Séquence: Lys 94-Ser 162

Attributs du produit: A DNA sequence encoding the Human NANOG protein (Q9H9S0) (Lys 94-Ser 162) was expressed with a N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Nanog (NANOG) (Nanog Homeobox (NANOG))

Autre désignation: NANOG (NANOG Produits)

Synonymes: 2410002E02Rik Protein, ENK Protein, ecat4 Protein, NANOG Protein, hacp Protein, wu:fd19e04 Protein, wu:fd20a07 Protein, zgc:193933 Protein, Nanog homeobox Protein, nanog homeobox Protein, Nanog Protein, NANOG Protein, nanog Protein

Sujet:

Abbreviation: NANOG

Target Synonym: Embryonic stem cell specific homeobox protein,ENK,FLJ12581,hNanog,Homeobox protein NANOG

Background: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.

Poids moléculaire:

Calculated MW: 7.48 kDa

Observed MW: 12 kDa

UniProt: Q9H9S0

Pathways: Stem Cell Maintenance