COL2A1 Protein (AA 1-268) (GST-His-Tag)
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- Antigène Voir toutes COL2A1 Protéines
- COL2A1 (Collagen, Type II, alpha 1 (COL2A1))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 1-268
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette COL2A1 protéine est marqué à la GST-His-Tag.
- Séquence
- Met 1-Leu 268
- Attributs du produit
- A DNA sequence encoding the Human COL2A1 protein (P02458-3) (Met 1-Leu 268) was expressed with a N-GST&C-His.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product COL2A1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- COL2A1 (Collagen, Type II, alpha 1 (COL2A1))
- Autre désignation
- COL2A1 (COL2A1 Produits)
- Synonymes
- ANFH Protein, AOM Protein, COL11A3 Protein, SEDC Protein, Col2 Protein, Col2a Protein, Col2a-1 Protein, Del1 Protein, Dmm Protein, Lpk Protein, M100856 Protein, Rgsc856 Protein, CG2A1A Protein, COLLII Protein, col2a1a Protein, CB11 Protein, col2a1 Protein, coll2a1 Protein, fb38c06 Protein, fc10c01 Protein, wu:fb38c06 Protein, wu:fc10c01 Protein, collagen type II alpha 1 chain Protein, collagen, type II, alpha 1 Protein, collagen, type II, alpha 1 L homeolog Protein, collagen, type II, alpha 1 S homeolog Protein, collagen, type II, alpha 1a Protein, COL2A1 Protein, Col2a1 Protein, col2a1 Protein, col2a1.L Protein, col2a1.S Protein, col2a1a Protein
- Sujet
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Abbreviation: COL2A1
Target Synonym: ANFH,AOM,COL11A3,SEDC,STL1
Background: COL2A1 is the alpha-1 chain of type II collagen which is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. Type II collagen is specific for cartilaginous tissues. Thus COL2A1 is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. The regulation of COL2A1, likely results from a balance of both positive and negative proteins. The inhibition of COL2A1 transcription following treatment of chick sternal chondrocytes with growth factors was accompanied by increased EF1 expression. Overexpression of EF1 in differentiated chondrocytes resulted in decreased expression of a reporter construct containing a collagen II promoter/enhancer insert.
- Poids moléculaire
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Calculated MW: 54.37 kDa
Observed MW: 54 kDa
- UniProt
- P02458-3
- Pathways
- Sensory Perception of Sound, Growth Factor Binding
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