SERPINB2 Protein (AA 19-415) (His tag)

N° du produit ABIN7505170

Détail du produit

Antigène: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Type de proteíne: Recombinant

Attributs du protein: AA 19-415

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SERPINB2 protéine est marqué à la His tag.

Séquence: Leu 19-Pro 415

Attributs du produit: A DNA sequence encoding the Human PAI-2 protein (P05120) (Leu 19-Pro 415) was expressed with N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Autre désignation: PAI-2 (SERPINB2 Produits)

Synonymes: HsT1201 Protein, PAI Protein, PAI-2 Protein, PAI2 Protein, PLANH2 Protein, SERPINB2 Protein, Planh2 Protein, ovalbumin Protein, Pai2a Protein, serpin family B member 2 Protein, serpin peptidase inhibitor, clade B (ovalbumin), member 2 Protein, serine (or cysteine) peptidase inhibitor, clade B, member 2 Protein, SERPINB2 Protein, Serpinb2 Protein

Classe de substances: Amino Acid

Sujet:

Abbreviation: PAI-2

Target Synonym: HsT1201;PAI;PAI-2;PAI2;PLANH2

Background: Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. SerpinB2, also known as Plasminogen activator inhibitor 2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor and PAI2, is a cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. SerpinB2 is a major product of activated monocytes and macrophages and is substantially induced during most inflammatory processes. Distinct from its widely described extracellular role as an inhibitor of urokinase plasminogen activator. SerpinB2 has been shown to have an intracellular role as a retinoblastoma protein (Rb)-binding protein that inhibits Rb degradation. SerpinB2 is widely described as an inhibitor of urokinase plasminogen activator. SerpinB2 inhibits urokinase-type plasminogen activator. The monocyte derived SerpinB2 is distinct from the endothelial cell-derived PAI-1. SerpinB2 is a potentially important inducible host factor that significantly promotes HIV-1 replication.

Poids moléculaire:

Calculated MW: 43.56 kDa

Observed MW: 45 kDa

UniProt: P05120

Pathways: Autophagy