Cyclin D1 Protein (CCND1) (AA 1-295) (His tag)
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- Antigène Voir toutes Cyclin D1 (CCND1) Protéines
- Cyclin D1 (CCND1)
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 1-295
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette Cyclin D1 protéine est marqué à la His tag.
- Séquence
- Met 1-Ile 295
- Attributs du produit
- A DNA sequence encoding the Human cyclin D1/Ccnd1 protein (P25322) (Met 1-Ile 295) was expressed with N-His.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CCND1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- Cyclin D1 (CCND1)
- Autre désignation
- cyclin D1 (CCND1 Produits)
- Synonymes
- BCL1 Protein, D11S287E Protein, PRAD1 Protein, U21B31 Protein, AI327039 Protein, CycD1 Protein, Cyl-1 Protein, bcl-1 Protein, cD1 Protein, cb161 Protein, cycd1 Protein, etID37810.7 Protein, fb52e01 Protein, fc45c08 Protein, fc83a12 Protein, id:ibd1198 Protein, wu:fb52e01 Protein, wu:fc45c08 Protein, wu:fc83a12 Protein, ccnd1b Protein, prad1 Protein, ccnd1 Protein, ccnd1a Protein, bcl1 Protein, d11s287e Protein, u21b31 Protein, CCND1 Protein, cyclin D1 Protein, cyclin D1 S homeolog Protein, cyclin D1 L homeolog Protein, CCND1 Protein, Ccnd1 Protein, ccnd1 Protein, ccnd1.S Protein, ccnd1.L Protein
- Sujet
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Abbreviation: cyclin D1,Ccnd1
Target Synonym: B cell leukemia 1,BCL 1,ccnd1,Cd1,Cyl 1,G1/S specific cyclin D1,PRAD1
Background: Activity of the cyclin-dependent kinases CDK4 and CDK6 is regulated by T-loop phosphorylation, by the abundance of their cyclin partners (the D-type cyclins), and by association with CDK inhibitors of the Cip/Kip or INK family of proteins. The inactive ternary complex of cyclin D/CDK4 and p27 Kip1 requires extracellular mitogenic stimuli for the release and degradation of p27 concomitant with a rise in cyclin D levels to affect progression through the restriction point and Rb-dependent entry into S-phase. The active complex of cyclin D/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression. Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of protein expression and phosphorylation-dependent degradation.
- Poids moléculaire
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Calculated MW: 32.34 kDa
Observed MW: 39 kDa
- UniProt
- P25322
- Pathways
- Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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