TGFBR3 Protein (AA 526-787) (His tag)
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- Antigène Voir toutes TGFBR3 Protéines
- TGFBR3 (Transforming Growth Factor, beta Receptor III (TGFBR3))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 526-787
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette TGFBR3 protéine est marqué à la His tag.
- Séquence
- Gln 526-Thr 787
- Attributs du produit
- A DNA sequence encoding the Human TGFBR3/ Betaglycan protein (Q03167) (Gln 526-Thr 787) was expressed with N-His tag.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product TGFBR3 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- TGFBR3 (Transforming Growth Factor, beta Receptor III (TGFBR3))
- Autre désignation
- TGFBR3 (TGFBR3 Produits)
- Synonymes
- TGFBR3 Protein, DKFZp469I0915 Protein, BGCAN Protein, betaglycan Protein, 1110036H20Rik Protein, AU015626 Protein, AW215636 Protein, TBRIII Protein, transforming growth factor beta receptor 3 Protein, transforming growth factor, beta receptor III Protein, TGFBR3 Protein, tgfbr3 Protein, Tgfbr3 Protein
- Sujet
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Abbreviation: TGFBR3;Betaglycan
Target Synonym: BGCAN
Background: Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.
- Poids moléculaire
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Calculated MW: 28.71 kDa
Observed MW: 35 kDa
- UniProt
- Q03167
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