MMP 9 Protein (AA 162-440) (His tag)

N° du produit ABIN7505187

Détail du produit

Antigène: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Type de proteíne: Recombinant

Attributs du protein: AA 162-440

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette MMP 9 protéine est marqué à la His tag.

Séquence: Arg 162-Arg 440

Attributs du produit: A DNA sequence encoding the Human MMP-9/CLG4B protein (P14780) (Arg 162-Arg 440) was expressed with N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Autre désignation: MMP-9 (MMP9 Produits)

Synonymes: CLG4B Protein, GELB Protein, MANDP2 Protein, MMP-9 Protein, AW743869 Protein, B/MMP9 Protein, Clg4b Protein, pro-MMP-9 Protein, mmp-9 Protein, fgMMP-9 Protein, mmp9 Protein, ZFMMP-9 Protein, wu:fb02g06 Protein, wu:fb07b05 Protein, wu:fi98c09 Protein, wu:fj05a08 Protein, zgc:64165 Protein, clg4b Protein, gelb Protein, mandp2 Protein, matrix metallopeptidase 9 Protein, collagenase Protein, matrix metalloproteinase 9 Protein, matrix metallopeptidase 9 S homeolog Protein, MMP9 Protein, RB3913 Protein, BPSS0666 Protein, Sbal_3732 Protein, Bcer98_0486 Protein, Shew185_0630 Protein, Shal_3056 Protein, Sbal195_0657 Protein, Lbys_3550 Protein, Palpr_2084 Protein, Mmp9 Protein, mmp9 Protein, mmp9.S Protein

Sujet:

Abbreviation: MMP-9,CLG4B

Target Synonym: Matrix metalloproteinase-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,MMP9,CLG4B,GELB,MANDP2

Background: Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. MMP9, also known as 92- kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. It plays an important role in tissue remodelling in normal and pathological inflammatory processes. MMP-9 is a major secretion product of macrophages and a component of cytoplasmic granules of neutrophils, and is particularly important in the pathogenesis of inflammatory, infectious, and neoplastic diseases in many organs including the lung. This enzyme is also secreted by lymphocytes and stromal cells upon stimulation by inflammatory cytokines, or upon delivery of bi-directional activation signals following integrin-mediated cell-cell or cell-extracellular matrix (ECM) contacts. The dramatic overexpression of MMP-9 in cancer and various inflammatory conditions clearly points to the molecular mechanisms controlling its expression as a potential target for eventual rational therapeutic intervention.

Poids moléculaire:

Calculated MW: 30.58 kDa

Observed MW: 35 kDa

UniProt: P14780

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events