CD147 Protein (AA 138-323) (His tag)

N° du produit ABIN7505205

Détail du produit

Antigène: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Type de proteíne: Recombinant

Attributs du protein: AA 138-323

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CD147 protéine est marqué à la His tag.

Séquence: Glu 138-Ala 323

Attributs du produit: A DNA sequence encoding the Human CD147/BSG/Basigin protein (P35613) (Glu 138-Ala 323) was expressed with N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Autre désignation: CD147 (BSG Produits)

Synonymes: EMMPRIN Protein, RPE7 Protein, 5F7 Protein, CD147 Protein, M6 Protein, OK Protein, TCSF Protein, AI115436 Protein, AI325119 Protein, HT-7 Protein, 5A11 Protein, CE9 Protein, HT7 Protein, Ox47R Protein, basignin Protein, wu:fb26a05 Protein, wu:fo98e12 Protein, bsg Protein, prso03 Protein, basigin (Ok blood group) Protein, basigin Protein, basigin (Ok blood group) S homeolog Protein, BSG Protein, Bsg Protein, bsg Protein, bsg.S Protein

Sujet:

Abbreviation: CD147,BSG,Basigin

Target Synonym: Basigin,5F7,Collagenase Stimulatory Factor,Extracellular Matrix Metalloproteinase Inducer,EMMPRIN,Leukocyte Activation Antigen M6,OK Blood Group Antigen,Tumor Cell-Derived Collagenase Stimulatory Factor,TCSF,CD147,BSG

Background: CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.

Poids moléculaire:

Calculated MW: 20.35 kDa

Observed MW: 25 kDa

UniProt: P35613

Pathways: S100 Proteins