GADD45A Protein (AA 1-165) (His tag)

N° du produit ABIN7505208

Détail du produit

Antigène: GADD45A (Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A))

Type de proteíne: Recombinant

Attributs du protein: AA 1-165

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GADD45A protéine est marqué à la His tag.

Séquence: Met 1-Arg 165

Attributs du produit: A DNA sequence encoding the Human GADD45A protein (P24522 ) (1M-165R) was expressed with N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: GADD45A (Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A))

Autre désignation: GADD45A (GADD45A Produits)

Synonymes: MGC53491 Protein, zgc:91795 Protein, gadd45a Protein, GADD45A Protein, ddit1 Protein, gadd45 Protein, GADD45 Protein, AA545191 Protein, Ddit1 Protein, DDIT1 Protein, Gadd45 Protein, growth arrest and DNA damage inducible alpha L homeolog Protein, growth arrest and DNA-damage-inducible, alpha, b Protein, growth arrest and DNA damage inducible alpha Protein, growth arrest and DNA damage-inducible protein 45 Protein, growth arrest and DNA-damage-inducible 45 alpha Protein, growth arrest and DNA-damage-inducible, alpha Protein, gadd45a.L Protein, gadd45ab Protein, GADD45A Protein, gadd45a Protein, GADD45 Protein, Gadd45a Protein

Sujet:

Abbreviation: GADD45A

Target Synonym: Growth arrest and DNA damage-inducible protein GADD45 alpha,GADD45A,DNA damage-inducible transcript 1 protein,

Background: GADD45 alpha (Growth arrest and DNA damage-inducible protein 45 alpha) is a 19 kDa member of the GADD45 family of proteins. It is ubiquitously expressed, and induced by DNA damage. Upon induction, GADD45 alpha binds to PCNA, stimulates DNA excision repair, and initiates G2 cell cycle arrest. Human GADD45 alpha is 165 amino acids (aa) in length. It is reported to dimerize with GADD45-beta and -gamma, and to homo-dimerize, -trimerize and -tetramerize via residues 33?61 and 133?165. There is one splice variant that shows a Ser substitution for aa 14?49. GADD45 alpha is 55 % aa identical to GADD45-beta and -gamma, and shares 94 % aa identity with mouse GADD45 alpha.

Poids moléculaire:

Calculated MW: 18.04 kDa

Observed MW: 23 kDa

UniProt: P24522

Pathways: Signalisation p53, Cycle Cellulaire