RAB5B Protein (AA 1-215) (His tag)

N° du produit ABIN7505212

Détail du produit

Antigène: RAB5B (RAB5B, Member RAS Oncogene Family (RAB5B))

Type de proteíne: Recombinant

Attributs du protein: AA 1-215

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette RAB5B protéine est marqué à la His tag.

Séquence: Met 1-Asn 215

Attributs du produit: A DNA sequence encoding the Human RAB5B protein (P61020) (Met 1-Asn 215) was expressed with a C-His,N-His.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: RAB5B (RAB5B, Member RAS Oncogene Family (RAB5B))

Autre désignation: RAB5B (RAB5B Produits)

Synonymes: zgc:76978 Protein, C030027M18Rik Protein, RAB5B, member RAS oncogene family Protein, RAB5B, member RAS oncogene family L homeolog Protein, rab5b Protein, LOC613071 Protein, RAB5B Protein, Rab5b Protein, rab5b.L Protein

Sujet:

Abbreviation: RAB5B

Target Synonym: Ras-related protein Rab-5B,RAB5B

Background: Antisense inhibition of Rab5b, a gene coding for a small GTPase associated with endocytosis, significantly reduced the mGluR-mediated neuroprotection. Ras-related protein Rab-5B (RAB5B), which is identified by a genome-wide association study as a risk locus for this syndrome, encodes a small GTPase involved in the control of receptor internalization and early endosome fusion. Previous genome-wide sequencing revealed that RAB5B is a susceptible target in patients with polycystic ovary syndrome (PCOS). RAB5A gene was abnormally expressed in luteinized granulosa cells of obese patients with polycystic ovary syndrome, which may help explain high FSHR levels found in this syndrome. RAB5B is directly downregulated by miR-130a-3p. Knockdown of RAB5B also inhibited cell proliferation, migration, and invasion.

Poids moléculaire:

Calculated MW: 23.54 kDa

Observed MW: 30 kDa

UniProt: P61020-1