CREB3L4 Protein (AA 14-295) (His tag)

N° du produit ABIN7505217

Détail du produit

Antigène: CREB3L4 (cAMP Responsive Element Binding Protein 3-Like 4 (CREB3L4))

Type de proteíne: Recombinant

Attributs du protein: AA 14-295

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CREB3L4 protéine est marqué à la His tag.

Séquence: Glu 14-Ser 295

Attributs du produit: A DNA sequence encoding the Human CREB3L4 protein (Q8TEY5) (Glu 14-Ser 295) was expressed with a C-His and N-His.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: CREB3L4 (cAMP Responsive Element Binding Protein 3-Like 4 (CREB3L4))

Autre désignation: CREB3L4 (CREB3L4 Produits)

Synonymes: CREB3L4 Protein, aibzip Protein, atce1 Protein, creb3 Protein, creb4 Protein, hjal Protein, jal Protein, tisp40 Protein, AIBZIP Protein, ATCE1 Protein, CREB3 Protein, CREB4 Protein, JAL Protein, hJAL Protein, 1700012K17Rik Protein, 5330432F22Rik Protein, AV040530 Protein, AV258827 Protein, Atce1 Protein, TISP40 Protein, Tisp40alpha Protein, Tisp40beta Protein, mJAL Protein, AIbZIP Protein, cAMP responsive element binding protein 3 like 4 Protein, cAMP responsive element binding protein 3-like 4 Protein, CREB3L4 Protein, creb3l4 Protein, Creb3l4 Protein

Sujet:

Abbreviation: CREB3L4

Target Synonym: Cyclic AMP-responsive element-binding protein 3-like protein 4,CREB3L4,cAMP-responsive element-binding protein 3-like protein 4,Androgen-induced basic leucine zipper protein (AIbZIP),Attaching to CRE-like 1 (ATCE1),Cyclic AMP-responsive element-binding pr

Background: The cyclic AMP responsive element-binding protein 3-like 4 (CREB3L4) is a transcription factor highly expressed in multiple human cancers. This study aimed to investigate the regulatory effects of CREB3L4 on GC progression and angiogenesis. CREB3L4 was overexpressed in GC tissues and cell lines, and was positively correlated with advanced tumor stage and poor survival in GC patients. The upregulation of CREB3L4 in GC cells increased cell viability, promoted cell proliferation, reduced apoptosis, enhanced cell migration and invasion, and induced the formation of tubule-like endothelial structures, whereas CREB3L4 knockdown impeded tumor cell growth, attenuated cell motility, and prevented human umbilical vein endothelial cells from forming tubule-like structures. In addition, mice inoculated with CREB3L4-deficient GC cells showed significantly suppressed tumor growth compared to the group harboring wild-type tumors.

Poids moléculaire:

Calculated MW: 32.186 kDa

Observed MW: 40 kDa

UniProt: Q8TEY5

Pathways: Thyroid Hormone Synthesis