Ataxin 3 Protein (ATXN3) (AA 1-370) (His tag)

N° du produit ABIN7505219

Détail du produit

Antigène: Ataxin 3 (ATXN3)

Type de proteíne: Recombinant

Attributs du protein: AA 1-370

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Ataxin 3 protéine est marqué à la His tag.

Séquence: Met 1-Lys 370

Attributs du produit: A DNA sequence encoding the Human ATXN3 protein (P54252-2) (Met 1-Lys 370) was expressed with a C-His and N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Ataxin 3 (ATXN3)

Autre désignation: Ataxin-3 (ATXN3 Produits)

Synonymes: Mjd Protein, zgc:56323 Protein, ATXN3 Protein, at3 Protein, jos Protein, mjd Protein, atx3 Protein, mjd1 Protein, sca3 Protein, ataxin-3 Protein, MJD1 Protein, MGC83584 Protein, AT3 Protein, ATX3 Protein, JOS Protein, MJD Protein, SCA3 Protein, 2210008M02Rik Protein, AI463012 Protein, AI647473 Protein, Sca3 Protein, Rsca3 Protein, ataxin 3 Protein, ataxin 3 L homeolog Protein, ataxin-3 Protein, atxn3 Protein, ATXN3 Protein, atxn3.L Protein, MICPUN_104046 Protein, MICPUCDRAFT_46658 Protein, Atxn3 Protein

Sujet:

Abbreviation: Ataxin-3,ATXN3

Target Synonym: Ataxin-3,ATXN3,Machado-Joseph disease protein1,Spinocerebellar ataxia type 3 protein

Background: Ataxin-3 is a ubiquitously expressed nuclear protein that serves as a deubiquitinating enzyme (DUB) involved in protein homeostasis and quality control, myogenesis and degradation of misfolded chaperone substrates. As a DUB, it has two distinct features. Its N-terminal Josephin domain confers cysteine protease activity to Ataxin-3 which is important for hydrolyzing ubiquitin (Ub) linkages. The second important feature is its three Ub-interacting motifs (UIMs) through which it binds Ub conjugates and ubiquitinated proteins and bring them into proximity to trim or edit specific linkages within these Ub conjugates. It binds long poly-Ub chains and trims them. However, it has weak or no activity against chains of 4 or less Ub.

Poids moléculaire:

Calculated MW: 40.59 kDa

Observed MW: 50 kDa

UniProt: P54252-2