Cyclin D2 Protein (CCND2) (AA 1-289) (His tag)

N° du produit ABIN7505225

Détail du produit

Antigène: Cyclin D2 (CCND2)

Type de proteíne: Recombinant

Attributs du protein: AA 1-289

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette Cyclin D2 protéine est marqué à la His tag.

Séquence: Met 1-Leu289

Attributs du produit: A DNA sequence encoding the Human CCND2 protein (P30279) (Met 1-Leu289) was expressed with aN-His&C-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Cyclin D2 (CCND2)

Autre désignation: Cyclin-D2 (CCND2 Produits)

Synonymes: si:ch211-240j22.2 Protein, ccnd2 Protein, CCND2 Protein, kiak0002 Protein, zgc:162280 Protein, LOC100224096 Protein, KIAK0002 Protein, BF642806 Protein, C86853 Protein, Vin-1 Protein, Vin1 Protein, cD2 Protein, 2600016F06Rik Protein, AI256817 Protein, cyclin D2, b Protein, cyclin D2 S homeolog Protein, cyclin D2 Protein, G1/S-specific cyclin-D2 Protein, cyclin D2, a Protein, cyclin D2 L homeolog Protein, ccnd2b Protein, ccnd2.S Protein, CCND2 Protein, ccnd2 Protein, ccnd2a Protein, Ccnd2 Protein, ccnd2.L Protein

Sujet:

Abbreviation: Cyclin-D2,CCND2

Target Synonym: G1/S-specific cyclin-D2,CCND2

Background: CCND2,also known as G1/S-specific cyclin-D2,is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such as phosphorylating and inhibiting members of the retinoblastoma (RB) protein family including RB1 and regulating the cell-cycle during G1/S transition. It is also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Poids moléculaire:

Calculated MW: 31.68 kDa

Observed MW: 38 kDa

UniProt: P30279

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases