SOCS2 Protein (AA 1-198) (His tag)

N° du produit ABIN7505230

Détail du produit

Antigène: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Type de proteíne: Recombinant

Attributs du protein: AA 1-198

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SOCS2 protéine est marqué à la His tag.

Séquence: Met 1-Val 198

Attributs du produit: A DNA sequence encoding the Human SOCS2 protein (O14508) (Met 1-Val 198) was expressed with a N-His&C-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Autre désignation: SOCS2 (SOCS2 Produits)

Synonymes: CIS2 Protein, Cish2 Protein, SOCS-2 Protein, SSI-2 Protein, SSI2 Protein, STATI2 Protein, Cish1 Protein, Socs-1 Protein, Socs-2 Protein, si:dkey-202b22.1 Protein, socs2 Protein, cis2 Protein, ssi2 Protein, cish2 Protein, ssi-2 Protein, socs-2 Protein, stati2 Protein, 8030460M17 Protein, AI527257 Protein, AW108012 Protein, D130043N08Rik Protein, JAB Protein, hg Protein, Cradd Protein, Socs2 Protein, suppressor of cytokine signaling 2 Protein, suppressor of cytokine signaling 1 Protein, death domain-containing protein CRADD Protein, suppressor of cytokine signaling 2 S homeolog Protein, SOCS2 Protein, Socs1 Protein, Socs2 Protein, socs2 Protein, LOC100716104 Protein, socs2.S Protein

Sujet:

Abbreviation: SOCS2

Target Synonym: Suppressor of cytokine signaling 2,SOCS2,Cytokine-inducible SH2 protein 2,STAT-induced STAT inhibitor 2

Background: SOCS-2 (Suppressor of cytokine signaling 2, also CIS-2 and SSI-2) is a 25 kDa member of the SOCS family of proteins. It is an SH2-domain containing cytoplasmic adaptor protein expressed by multiple cell types. It blocks receptor signaling by binding to phosphorylated tyrosines in the cytoplasmic domain of select receptors, including the receptors for leptin, IGF-I and GH. Human SOCS-2 is 198 amino acids (aa) in length and contains one SH2 domain (aa 48?156) and a SOCS box (aa 160?198) that mediates interaction with elongin B or C of the E3 ubiquitin ligase complex. There is one splice variant that shows an Arg-rich eight aa substitution for aa 31?39. Full-length SOCS-2 is 94 % and 96 % aa identical to mouse and porcine SOCS-2, respectively.

Poids moléculaire:

Calculated MW: 21.67 kDa

Observed MW: 25 kDa

UniProt: O14508

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus