SCO2 Protein (AA 42-266) (His tag)

N° du produit ABIN7505240

Détail du produit

Antigène: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Type de proteíne: Recombinant

Attributs du protein: AA 42-266

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SCO2 protéine est marqué à la His tag.

Séquence: Gly 42-Ser 266

Attributs du produit: A DNA sequence encoding the Human SCO2 protein (O43819) (Gly 42-Ser 266) was expressed with aN-His&C-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Autre désignation: SCO2 (SCO2 Produits)

Synonymes: CEMCOX1 Protein, MYP6 Protein, SCO1L Protein, SCO cytochrome oxidase deficient homolog 2 (yeast) Protein, SCO2 cytochrome c oxidase assembly protein Protein, SCO2, cytochrome c oxidase assembly protein Protein, SCO2 Protein, Sco2 Protein

Sujet:

Abbreviation: SCO2

Target Synonym: Protein SCO2 homolog,mitochondrial,SCO2,

Background: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) . This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.

Poids moléculaire:

Calculated MW: 24.64 kDa

Observed MW: 30 kDa

UniProt: O43819

Pathways: Transition Metal Ion Homeostasis, L'effet Warburg