RAB5 Protein (AA 1-215) (His tag)

N° du produit ABIN7505252

Détail du produit

Antigène: RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

Type de proteíne: Recombinant

Attributs du protein: AA 1-215

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette RAB5 protéine est marqué à la His tag.

Séquence: Met 1-Asn 215

Attributs du produit: A DNA sequence encoding the Human RAB5A protein (P20339) (Met 1-Asn 215) was expressed with a N-His&C-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))

Autre désignation: RAB5A (RAB5A Produits)

Synonymes: RAB5 Protein, 2410015H04Rik Protein, AI663973 Protein, AU021172 Protein, nnyRab5a Protein, DDBDRAFT_0168594 Protein, DDBDRAFT_0229401 Protein, DDB_0168594 Protein, DDB_0229401 Protein, rab5 Protein, RAB5A Protein, Rab5a Protein, rab5al Protein, zgc:56644 Protein, fj38g08 Protein, hm:zehn1144 Protein, rab5a Protein, wu:fj38g08 Protein, RAB5A, member RAS oncogene family Protein, rab5A protein Protein, Rab5a, GTPase Protein, predicted protein Protein, Rab GTPase Protein, RAB5A, member RAS oncogene family L homeolog Protein, RAB5A, member RAS oncogene family, b Protein, RAB5A, member RAS oncogene family, a Protein, RAB5A Protein, Rab5a Protein, rab5A Protein, rab5a Protein, rab5a.L Protein, rab5ab Protein, rab5aa Protein

Sujet:

Abbreviation: RAB5A

Target Synonym: Ras-related protein Rab-5A,RAB5A

Background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.

Poids moléculaire:

Calculated MW: 23.54 kDa

Observed MW: 32 kDa

UniProt: P20339

Pathways: Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity