PKD1 Protein (AA 177-359) (His tag)
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- Antigène Voir toutes PKD1 Protéines
- PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 177-359
- Origine
- Humain
- Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette PKD1 protéine est marqué à la His tag.
- Séquence
- Gly 177-Leu 359
- Attributs du produit
- A DNA sequence encoding the Human PKD1 protein (P98161) (Gly 177-Leu 359) was expressed with a N-His tag.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
- Autre désignation
- PKD1 (PKD1 Produits)
- Synonymes
- PBP Protein, Pc-1 Protein, TRPP1 Protein, PC1 Protein, mFLJ00285 Protein, polycystin 1, transient receptor potential channel interacting Protein, polycystin 1, transient receptor poteintial channel interacting Protein, polycystin-1 Protein, PKD1 Protein, Pkd1 Protein, LOC749291 Protein
- Sujet
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Abbreviation: PKD1
Target Synonym: Polycystin-1,PKD1,Autosomal dominant polycystic kidney disease 1 protein
Background: Polycystin-1 (also PKD1) is a 500-550 kDa member of the polycystin family of proteins. It is expressed in renal tubule primary cilia, and the membrane region that forms adherens junctions. Polycystin-1 binds to polycystin-2, promoting its insertion into the cell membrane, and regulating its calcium channel activity. In conjunction with polycystin-2, it detects fluid flow and converts this information into calcium signals. It also exists in the ER, where it negatively modulates polycystin-2 mediated calcium release. Mature human polycystin-1 is a 4280 amino acid (aa), 11 transmembrane glycoprotein.
- Poids moléculaire
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Calculated MW: 20.02 kDa
Observed MW: 22 kDa
- UniProt
- P98161
- Pathways
- Myometrial Relaxation and Contraction, Maintenance of Protein Location
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