MCM8 Protein (AA 1-250) (His tag)

N° du produit ABIN7505291

Détail du produit

Antigène: MCM8 (Minichromosome Maintenance Deficient 8 (MCM8))

Type de proteíne: Recombinant

Attributs du protein: AA 1-250

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette MCM8 protéine est marqué à la His tag.

Séquence: Met 1-Ser 250

Attributs du produit: A DNA sequence encoding the Human MCM8 protein (Q9UJA3) (Met 1-Ser 250) was expressed with a C-His,N-His.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: MCM8 (Minichromosome Maintenance Deficient 8 (MCM8))

Autre désignation: MCM8 (MCM8 Produits)

Synonymes: C20orf154 Protein, dJ967N21.5 Protein, 5730432L01Rik Protein, minichromosome maintenance 8 homologous recombination repair factor Protein, minichromosome maintenance 8 homologous recombination repair factor L homeolog Protein, MCM8 Protein, Mcm8 Protein, mcm8.L Protein

Sujet:

Abbreviation: MCM8

Target Synonym: DNA helicase MCM8,MCM8,Minichromosome maintenance 8

Background: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.

Poids moléculaire:

Calculated MW: 27.39 kDa

Observed MW: 35 kDa

UniProt: Q9UJA3-1

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA