FGF18 Protein (AA 31-207) (His tag)
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- Antigène Voir toutes FGF18 Protéines
- FGF18 (Fibroblast Growth Factor 18 (FGF18))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 31-207
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette FGF18 protéine est marqué à la His tag.
- Séquence
- Val 31-Ala 207
- Attributs du produit
- A DNA sequence encoding the Human FGF18 protein (O76093) (Val 31-Ala 207) was expressed with a C-His tag.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product FGF18 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- FGF18 (Fibroblast Growth Factor 18 (FGF18))
- Autre désignation
- FGF18 (FGF18 Produits)
- Synonymes
- FGF-18 Protein, ZFGF5 Protein, D130055P09Rik Protein, fgf18 Protein, FGF18 Protein, fgf18l Protein, fibroblast growth factor 18 Protein, fibroblast growth factor 18a Protein, fibroblast growth factor 18b Protein, FGF18 Protein, Fgf18 Protein, fgf18a Protein, Tsp_09844 Protein, fgf18b Protein
- Sujet
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Abbreviation: FGF18
Target Synonym: FGFI,zFGF5
Background: Fibroblast Growth Factor 18 (FGF-18) is a 20 kDa protein that plays an important role in skeletal development and bone homeostasis . Mature human FGF-18 shares 99 % amino acid sequence identity with mouse and rat FGF-18 . It is expressed in embryonic somites and the neural fold , adult lung , cerebellar and hippocampal neurons , hair follicle root sheath cells , and osteogenic mesenchymal cells . FGF-18 binds to FGF R2c, FGF R3c as well as the Golgi protein GLG1 and induces the proliferation of astrocytes and microglia, vascular endothelial cells, dermal fibroblasts, papilla cells, and keratinocytes . FGF-18 is required for normal skeletal development . It recruits osteoclasts and osteoblasts to the growth plate, promotes osteoclast formation and function, inhibits osteoblast differentiation, promotes skeletal vascularization, and induces chondrocyte hypertrophy and cartilage matrix formation.
- Poids moléculaire
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Calculated MW: 19.36 kDa
Observed MW: 23 kDa
- UniProt
- O76093
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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