E2F2 Protein (AA 65-437) (His tag)
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- Antigène Voir toutes E2F2 Protéines
- E2F2 (E2F Transcription Factor 2 (E2F2))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 65-437
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette E2F2 protéine est marqué à la His tag.
- Séquence
- Ala 65-Asn 437
- Attributs du produit
- A DNA sequence encoding the Human E2F2 protein (Q14209) (Ala 65-Asn 437) was expressed with a N-His tag.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product E2F2 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
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- Antigène
- E2F2 (E2F Transcription Factor 2 (E2F2))
- Autre désignation
- E2F2 (E2F2 Produits)
- Synonymes
- E2F-2 Protein, CG1071 Protein, Dmel\\CG1071 Protein, E2F Protein, E2F2 Protein, dE2F-2 Protein, dE2F2 Protein, dE2f2 Protein, de2f2 Protein, e2f2 Protein, 9230110J10 Protein, E130207A07 Protein, fb40b03 Protein, wu:fb40b03 Protein, E2F transcription factor 2 Protein, si:ch211-160f23.5 Protein, E2F2 Protein, E2f2 Protein, si:ch211-160f23.5 Protein
- Sujet
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Abbreviation: E2F2
Target Synonym: Transcription factor E2F2,E2F2,
Background: E2F-2 (viral E2-associated factor 2) is a 50?55 kDa member of the E2F/DP family of transcription factors. It is principally expressed by placenta, and forms a DNA?activating E2F heterodimeric complex with DP-1 or -2. This complex, when active, promotes cell cycle progression. In quiescent cells, association with the retinoblastoma-tumor suppressor gene product termed pRB suppresses its activity. Human E2F?2 is 437 amino acids (aa) in length and contains a CDK2 binding region (aa 65?105), a DNA?binding domain (aa 107?196), a dimerization segment (aa 197?289), a transactivation region (aa 359?437), and a pRB binding domain (aa 410?427). There are two potential alternate start sites at Met197 and Met342, and one splice variant that shows a two aa substitution for aa 349?437.
- Poids moléculaire
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Calculated MW: 40.92 kDa
Observed MW: 55 kDa
- UniProt
- Q14209
- Pathways
- Cycle Cellulaire, Mitotic G1-G1/S Phases, DNA Replication
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