OPTN Protein (AA 1-353) (His tag)

N° du produit ABIN7505337

Détail du produit

Antigène: OPTN (Optineurin (OPTN))

Type de proteíne: Recombinant

Attributs du protein: AA 1-353

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette OPTN protéine est marqué à la His tag.

Séquence: Met1-353Glu

Attributs du produit: A DNA sequence encoding the Human OPTN protein (Q96CV9) (Met1-353Glu) was expressed with a N-His tag.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: OPTN (Optineurin (OPTN))

Autre désignation: OPTN (OPTN Produits)

Synonymes: nrp Protein, fip2 Protein, hip7 Protein, hypl Protein, glc1e Protein, tfiiia-intp Protein, ALS12 Protein, FIP2 Protein, GLC1E Protein, HIP7 Protein, HYPL Protein, NRP Protein, TFIIIA-INTP Protein, Fip2 Protein, 4930441O07Rik Protein, fj52f04 Protein, si:ch211-240l19.3 Protein, wu:fj52f04 Protein, zgc:66386 Protein, zgc:77868 Protein, optineurin Protein, optineurin L homeolog Protein, OPTN Protein, optn Protein, Optn Protein, optn.L Protein

Sujet:

Abbreviation: OPTN

Target Synonym: Optineurin,OPTN,

Background: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Poids moléculaire:

Calculated MW: 38.72 kDa

Observed MW: 45 kDa

UniProt: Q96CV9

Pathways: M Phase