S100B Protein (AA 1-92) (His tag)
-
- Antigène Voir toutes S100B Protéines
- S100B (S100 Calcium Binding Protein B (S100B))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 1-92
-
Origine
- Souris
-
Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette S100B protéine est marqué à la His tag.
- Séquence
- Met1-Glu92
- Attributs du produit
- Recombinant Mouse S100 Calcium Binding Protein B is produced by our E.coli expression system and the target gene encoding Met1-Glu92 is expressed with a 6His tag at the C-terminus.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- <1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product S100B Protéine
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
-
Lyophilized from a 0.2 um filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Date de péremption
- 12 months
-
- Antigène
- S100B (S100 Calcium Binding Protein B (S100B))
- Autre désignation
- S100B (S100B Produits)
- Synonymes
- NEF Protein, S100 Protein, S100-B Protein, S100beta Protein, S100P Protein, AI850290 Protein, Bpb Protein, si:dkey-110p14.2 Protein, wu:fq18b10 Protein, zgc:92776 Protein, S100 calcium binding protein B Protein, S100 protein, beta polypeptide, neural Protein, S100 calcium binding protein, beta (neural) Protein, S100B Protein, S100b Protein, s100b Protein
- Sujet
-
Abbreviation: S100B
Target Synonym: Protein S100-B,S-100 protein beta chain,S-100 protein subunit beta,S100 calcium-binding protein B,S100b,S100 beta,S100 calcium binding protein B
Background: S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytes are the major cells producing S100-B protein in gray matter, as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition, S100-B, which is also present in Mouse melanocytes, is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.
- Poids moléculaire
-
Calculated MW: 11.8 kDa
Observed MW: 12 kDa
- UniProt
- P50114
- Pathways
- Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins
-